Article
A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans.
Diabetes - 1 Apr 2005
Lehman Donna M, Fu Dong-Jing, Freeman Angela B, Hunt Kelly J, Leach Robin J, Johnson-Pais Teresa, Hamlington Jeanette, Dyer Thomas D, Arya Rector, Abboud Hanna, Göring Harald H H, Duggirala Ravindranath, Blangero John, Konrad Robert J, Stern Michael P
Abstract excerpt
Excess O-glycosylation of proteins by O-linked beta-N-acetylglucosamine (O-GlcNAc) may be involved in the pathogenesis of type 2 diabetes. The enzyme O-GlcNAc-selective N-acetyl-beta-d glucosaminidase (O-GlcNAcase) encoded by MGEA5 on 10q24.1-q24.3 reverses this modification by catalyzing the removal of O-GlcNAc. We have previously reported the linkage of type 2 diabetes and age at diabetes onset to an...
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