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Article

Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.

Diabetic medicine : a journal of the British Diabetic Association - 1 Apr 2005

Sagen J V, Pearson E R, Johansen A, Spyer G, Søvik O, Pedersen O, Njølstad P R, Hattersley A T, Hansen T

Abstract excerpt

AIMS: Diabetic subjects with mutations in the gene encoding hepatocyte nuclear factor (HNF)-1alpha (MODY3) are prone to develop hypoglycaemia at low doses of glibenclamide, interpreted as sulphonylurea hypersensitivity. The present study was undertaken to compare the plasma insulin responses to glucose and tolbutamide in HNF-1alpha mutation carriers with those of healthy control subjects. METHODS: Seven mutation...

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Source

Identifiers

PMID: 15787664
DOI: 10.1111/j.1464-5491.2005.01439.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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