Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas.

doi:10.2337/dc18-0384

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Article

Mexican Carriers of the HNF1A p.E508K Variant Do Not Experience an Enhanced Response to Sulfonylureas.

Diabetes care - 1 Aug 2018

Martagón Alexandro J, Bello-Chavolla Omar Yaxmehen, Arellano-Campos Olimpia, Almeda-Valdés Paloma, Walford Geoffrey A, Cruz-Bautista Ivette, Gómez-Velasco Donají V, Mehta Roopa, Muñoz-Hernández Liliana, Sevilla-González Magdalena, Viveros-Ruiz Tannia L, Ordoñez-Sánchez María Luisa, Rodríguez-Guillen Rosario, Florez Jose C, Tusié-Luna María Teresa, Aguilar-Salinas Carlos A

Abstract excerpt

OBJECTIVE: To assess whether an ethnic-specific variant (p.E508K) in the maturity-onset diabetes of the young (MODY) gene hepatocyte nuclear factor-1α (HNF1A) found in Mexicans is associated with higher sensitivity to sulfonylureas, as documented in patients with MODY3. RESEARCH DESIGN AND METHODS: We recruited 96 participants (46 variant carriers and 50 age- and sex-matched noncarriers). Response to glipizide...

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PMID: 29844095
DOI: 10.2337/dc18-0384

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