Article
Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2005
Zhao Xing, Lorenc Heather, Stephenson Heather, Wang Yunjiao Joy, Witherspoon Dawn, Katzenellenbogen Benita, Pfaff Donald, Vasudevan Nandini
Abstract excerpt
Thyroid hormones (T) and estrogens (E) are nuclear receptor ligands with at least two molecular mechanisms of action: (i) relatively slow genomic effects, such as the regulation of transcription by cognate T receptors (TR) and E receptors (ER); and (ii) relatively rapid nongenomic effects, such as kinase activation and calcium release initiated at the membrane by putative membrane receptors. Genomic and...
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