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Article

WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.

Journal of leukocyte biology - 1 Jun 2005

Snapper Scott B, Meelu Parool, Nguyen Deanna, Stockton Britt M, Bozza Patricia, Alt Frederick W, Rosen Fred S, von Andrian Ulrich H, Klein Christoph

Abstract excerpt

Intact cellular migration is critically important for the induction and regulation of the immune response. The Wiskott-Aldrich syndrome protein (WASP) regulates surface receptor signaling to the actin cytoskeleton in hematopoietic cells and thus plays a pivotal role in cellular locomotion. WASP deficiency causes the Wiskott-Aldrich syndrome (WAS), characterized by immunodeficiency, thrombocytopenia, and eczema....

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Source

Identifiers

PMID: 15774550
DOI: 10.1189/jlb.0804444

Genes

CCL19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo.PMID 15774550Read ↗

Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response.Semantic proximity Read ↗

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activationSemantic proximity Read ↗

Intrinsic dendritic cell abnormalities in Wiskott-Aldrich syndromeSemantic proximity Read ↗

WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1αSemantic proximity Read ↗

Expression of Wiskott-Aldrich Syndrome Protein in Dendritic Cells Regulates Synapse Formation and Activation of Naive CD8+ T CellsSemantic proximity Read ↗

Chemotaxis of macrophages is abolished in the Wiskott‐Aldrich syndromeSemantic proximity Read ↗

Mechanisms of WASp-mediated hematologic and immunologic disease.Semantic proximity Read ↗

Wiskott–Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cellsSemantic proximity Read ↗

Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes.Semantic proximity Read ↗

WASP and WIP regulate podosomes in migrating leukocytesSemantic proximity Read ↗

Hematopoietic Lineage Cell-Specific Protein 1 Functions in Concert with the Wiskott–Aldrich Syndrome Protein To Promote Podosome Array Organization and Chemotaxis in Dendritic CellsSemantic proximity Read ↗

WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and functionSemantic proximity Read ↗

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