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Article

Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.

Molecular and cellular biology - 1 Apr 2005

Sommariva Elena, Pellny Till K, Karahan Nilay, Kumar Sanjay, Huberman Joel A, Dalgaard Jacob Z

Abstract excerpt

The Swi1 and Swi3 proteins are required for mat1 imprinting and mating-type switching in Schizosaccharomyces pombe, where they mediate a pause of leading-strand replication in response to a lagging-strand signal. In addition, Swi1 has been demonstrated to be involved in the checkpoint response to stalled replication forks, as was described for the Saccharomyces cerevisiae homologue Tof1. This study addresses the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15767681
DOI: 10.1128/MCB.25.7.2770-2784.2005
PMCID: PMC1061638

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Schizosaccharomyces pombe Swi1, Swi3, and Hsk1 are components of a novel S-phase response pathway to alkylation damage.PMID 15767681Read ↗

Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex.Semantic proximity Read ↗

DNA polymerase α (swi7) and the flap endonuclease Fen1 (rad2) act together in the S-phase alkylation damage response in S. pombe.Semantic proximity Read ↗

Role of swi7H4 mutant allele of DNA polymerase α in the DNA damage checkpoint response.Semantic proximity Read ↗

Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.Semantic proximity Read ↗

Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.Semantic proximity Read ↗

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Semantic proximity Read ↗

Rad53 checkpoint kinase phosphorylation site preference identified in the Swi6 protein of Saccharomyces cerevisiae.Semantic proximity Read ↗

The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects.Semantic proximity Read ↗

Biochemical interactions between proteins and mat1 cis-acting sequences required for imprinting in fission yeast.Semantic proximity Read ↗

Fission yeast Hsk1 (Cdc7) kinase is required after replication initiation for induced mutagenesis and proper response to DNA alkylation damage.Semantic proximity Read ↗

Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response.Semantic proximity Read ↗

Different domains of Sgs1 are required for mitotic and meiotic functions.Semantic proximity Read ↗

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