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Article

Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.

Molecular and cellular biology - 1 Apr 2005

Jiang Wei-Qin, Zhong Ze-Huai, Henson Jeremy D, Neumann Axel A, Chang Andy C-M, Reddel Roger R

Abstract excerpt

Approximately 10% of cancers overall use alternative lengthening of telomeres (ALT) instead of telomerase to prevent telomere shortening, and ALT is especially common in astrocytomas and various types of sarcomas. The hallmarks of ALT in telomerase-negative cancer cells include a unique pattern of telomere length heterogeneity, rapid changes in individual telomere lengths, and the presence of ALT-associated...

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Source

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Identifiers

PMID: 15767676
DOI: 10.1128/MCB.25.7.2708-2721.2005
PMCID: PMC1061646

Genes

RAD50
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.PMID 15767676Read ↗

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