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Article

Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability.

Molecular and cellular biology - 1 Apr 2005

Shafer Beth, Chu Chun, Shatkin Aaron J

Abstract excerpt

A characteristic feature of gene expression in eukaryotes is the addition of a 5'-terminal 7-methylguanine cap (m7GpppN) to nascent pre-mRNAs in the nucleus catalyzed by capping enzyme and cap methyltransferase. Small interfering RNA (siRNA) knockdown of cap methyltransferase in HeLa cells resulted in apoptosis as measured by terminal deoxynucleotidyltransferase-mediated dUTP-tetramethylrhodamine nick end...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15767670
DOI: 10.1128/MCB.25.7.2644-2649.2005
PMCID: PMC1061643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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