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Inflammation, genetics, and ischemic heart disease: focus on the major histocompatibility complex (MHC) genes.

Cytokine - 7 Mar 2005

Porto Italo, Leone Antonio Maria, Crea Filippo, Andreotti Felicita

Abstract excerpt

BACKGROUND: Increasing data suggest that ischemic heart disease (IHD) shares several characteristics with common inflammatory diseases (such as rheumatoid arthritis), in which the pathogenetic role of inflammatory gene polymorphisms is well established. Variants in the genes for the major histocompatibility complex (MHC) molecules on the short arm of chromosome 6 show profound "linkage disequilibrium", leading to...

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PMID: 15760675
DOI: 10.1016/j.cyto.2004.09.010

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