Article
Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis.
The Journal of biological chemistry - 13 May 2005
Lüer Corinna, Schauer Stefan, Möbius Kalle, Schulze Jörg, Schubert Wolf-Dieter, Heinz Dirk W, Jahn Dieter, Moser Jürgen
Abstract excerpt
In Escherichia coli the first common precursor of all tetrapyrroles, 5-aminolevulinic acid, is synthesized from glutamyl-tRNA (Glu-tRNA(Glu)) in a two-step reaction catalyzed by glutamyl-tRNA reductase (GluTR) and glutamate-1-semialdehyde 2,1-aminomutase (GSA-AM). To protect the highly reactive reaction intermediate glutamate-1-semialdehyde (GSA), a tight complex between these two enzymes was proposed based on...
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