Article
Genome-wide screen for prostate cancer susceptibility genes in men with clinically significant disease.
The Prostate - 1 Sept 2005
Chang Bao-Li, Isaacs Sarah D, Wiley Kathy E, Gillanders Elizabeth M, Zheng S Lilly, Meyers Deborah A, Walsh Patrick C, Trent Jeffrey M, Xu Jianfeng, Isaacs William B
Abstract excerpt
BACKGROUND: One of the difficulties confronting genetic studies of prostate cancer is the complex and heterogeneous etiology. Given the high population frequency of lesions meeting the histological definition of prostate cancer, a significant portion of men with a positive family history may be diagnosed due to increased surveillance and associated higher likelihood of biopsy. Over diagnosis decreases power to...
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