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Article

Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity.

Cancer research - 1 Mar 2005

Basciani Sabrina, Brama Marina, Mariani Stefania, De Luca Gabriele, Arizzi Mario, Vesci Loredana, Pisano Claudio, Dolci Susanna, Spera Giovanni, Gnessi Lucio

Abstract excerpt

Leydig cell tumors are usually benign tumors of the male gonad. However, if the tumor is malignant, no effective treatments are currently available. Leydig cell tumors express platelet-derived growth factor (PDGF), kit ligand and their respective receptors, PDGFR and c-kit. We therefore evaluated the effects of imatinib mesylate (imatinib), a selective inhibitor of the c-kit and PDGFR tyrosine kinases, on the...

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PMID: 15753388
DOI: 10.1158/0008-5472.CAN-04-2181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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