Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β.

BMC cancer - 4 May 2013

Ohishi Jun, Aoki Mikiko, Nabeshima Kazuki, Suzumiya Junji, Takeuchi Tamotsu, Ogose Akira, Hakozaki Michiyuki, Yamashita Yuichi, Iwasaki Hiroshi

Abstract excerpt

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive and associated with poor prognosis. Basic research to develop new treatment regimens is critically needed. METHODS: The effects of imatinib mesylate on MPNSTs were examined in six human MPNST cell lines and in a xenograft mouse model. RESULTS: The results showed expression of platelet-derived growth factor receptor-β and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Imatinib Mesylate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Neoplastic Stem Cells

Share to Nerve Sheath Neoplasms

Share to Receptor, Platelet-Derived Growth Factor alpha

Share to Receptor, Platelet-Derived Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 23642185
DOI: 10.1186/1471-2407-13-224
PMCID: PMC3654969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β.PMID 23642185Read ↗

Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB.Semantic proximity Read ↗

Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivitySemantic proximity Read ↗

Imatinib mesylate inhibits Leydig cell tumor growth: evidence for in vitro and in vivo activity.Semantic proximity Read ↗

STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors.Semantic proximity Read ↗

PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor.Semantic proximity Read ↗

Preliminary in vitro and in vivo investigation of a potent platelet derived growth factor receptor (PDGFR) family kinase inhibitor.Semantic proximity Read ↗

Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.Semantic proximity Read ↗

Antiproliferation effect of imatinib mesylate on MCF7, T-47D tumorigenic and MCF 10A nontumorigenic breast cell lines via PDGFR-β, PDGF-BB, c-Kit and SCF genesSemantic proximity Read ↗

Malignant peripheral nerve sheath tumor cell invasion is facilitated by Src and aberrant CD44 expression.Semantic proximity Read ↗

Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BBSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.