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Inhibitory effect of imatinib on normal progenitor cells in vitro

16 Sept 2003

Abstract excerpt

Imatinib is a novel tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive leukemias and other malignancies. Side effects are mostly moderate; however, a dose-dependent hematologic toxicity affecting all hematopoietic lineages is observed clinically. The aim of this study was to investigate the effect of imatinib on normal hematopoietic stem and progenitor cells in vitro. A...

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PMID: 12969987
DOI: 10.1182/blood-2003-05-1535

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