Article
A clinical and biological overview of gastrointestinal stromal tumors.
Medical oncology (Northwood, London, England) - 1 Jan 2005
Candelaria Myrna, de la Garza Jaime, Duenas-Gonzalez Alfonso
Abstract excerpt
In the last few years a body of knowledge has been generated on the molecular basis of gastrointestinal stromal tumors (GIST). These mesenchymal tumors are characterized by the expression of KIT protein and because they have an activating mutation in a class III receptor tyrosine kinase gene (KIT or PDGFRA). Several KIT-activating mutations, which are largely responsible for the development of this tumor, promote...
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