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Article

Determinants of age at onset in a Portuguese cohort of autosomal dominant spastic paraplegia.

Journal of the neurological sciences - 15 Mar 2020

Rodrigues Rita, Silva Renata, Branco Mariana, Brandão Eva, Alonso Isabel, Ruano Luís, Loureiro José Leal

Abstract excerpt

BACKGROUND: Hereditary spastic paraplegias present a high variability of age at onset, ranging from childhood to older age. Our objective was to identify the determinants of age at onset in autosomal dominant HSP (AD-HSP) in a large cohort of patients and families. METHODS: We included 239 patients from 89 families identified in the Portuguese multisource population-based survey of hereditary ataxias and spastic...

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Identifiers

PMID: 31887672
DOI: 10.1016/j.jns.2019.116646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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