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Article

Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.

Molecular and cellular neurosciences - 1 Mar 2005

Sonntag Kai-Christian, Simantov Rabi, Björklund Lars, Cooper Oliver, Pruszak Jan, Kowalke Florian, Gilmartin Jocelyn, Ding Jixiang, Hu Ya-Ping, Shen Michael M, Isacson Ole

Abstract excerpt

Activation of transforming growth factor-beta (TGF-beta) receptors typically elicits mesodermal development, whereas inhibition of this pathway induces neural fates. In vitro differentiated mouse embryonic stem (ES) cells with deletion of the TGF-beta pathway-related factors Smad4 or Cripto exhibited increased numbers of neurons. Cripto-/- ES cells developed into neuroecto-/epidermal cell types, while Smad4-/-...

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PMID: 15737733
DOI: 10.1016/j.mcn.2004.06.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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