Article
The plasticity of aging: insights from long-lived mutants.
Cell - 25 Feb 2005
Kenyon Cynthia
Abstract excerpt
Mutations in genes affecting endocrine signaling, stress responses, metabolism, and telomeres can all increase the life spans of model organisms. These mutations have revealed evolutionarily conserved pathways for aging, some of which appear to extend life span in response to sensory cues, caloric restriction, or stress. Many mutations affecting longevity pathways delay age-related disease, and the molecular...
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