Article
The genetics of aging.
Current opinion in genetics & development - 1 Jun 2002
Perls Thomas, Kunkel Louis, Puca Annibale
Abstract excerpt
Once thought to be an extremely complex conundrum of weak genetic and environmental effects, exceptional longevity is beginning to yield genetic findings. Numerous lower organism and mammalian models demonstrate genetic mutations that increase life-span markedly. These variations, some of them evolutionarily conserved, inform us about biochemical pathways that significantly impact upon longevity. Centenarian...
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