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Article

Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.

FEBS letters - 28 Feb 2005

Cheng Wen-Hsing, Sakamoto Shuichi, Fox Jennifer T, Komatsu Kenshi, Carney James, Bohr Vilhelm A

Abstract excerpt

The WRN protein is mutated in the chromosomally unstable Werner syndrome (WS) and the Nbs1 protein is mutated in Nijmegen breakage syndrome (NBS). The Nbs1 protein is an integral component of the M/R/N complex. Although WRN is known to interact with this complex in response to gamma-irradiation,...

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Source

Identifiers

PMID: 15733840
DOI: 10.1016/j.febslet.2005.01.028

Genes

WRN
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15733840-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.PMID 15733840Read ↗

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CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choiceSemantic proximity Read ↗

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Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factorsSemantic proximity Read ↗

DNA Damage-induced Translocation of the Werner Helicase Is Regulated by AcetylationSemantic proximity Read ↗

Werner syndrome protein contains three structure-specific DNA binding domains.Semantic proximity Read ↗

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Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrestSemantic proximity Read ↗

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