Article
The role of interleukin 4 and IL-4RA in intervertebral disc degeneration: investigation of single nucleotide polymorphisms in genes and a systematic review & meta-analysis of IL-4 expression level.
British journal of neurosurgery - 1 Feb 2020
Hanaei Sara, Abdollahzade Sina, Sadr Maryam, Mirbolouk Mohammad Hossein, Fattahi Ehsan, Khoshnevisan Alireza, Rezaei Nima
Abstract excerpt
Background: Intervertebral disc degeneration (IVDD) is a multifactorial disease that is sensitive to the balance between anti-inflammatory and pro-inflammatory cytokines. This study investigated the single nucleotide polymorphisms (SNPs) of interleukin 4 (IL-4) in IVDD.Methods: Genomic DNA of peripheral mononuclear cells of 76 IVDD patients and 140 healthy controls were investigated for three SNPs of IL-4...
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