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Article

Simultaneous fluorescence immunophenotyping and Her-2/neu genotyping (FICTION) in breast carcinoma candidates to target therapy.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jul 2012

Gatta Luisa Benerini, Incardona Paolo, Cadei Moris, Grigolato Piergiovanni, Simoncelli Sabrina, Balzarini Piera

Abstract excerpt

The study of proto-oncogene Her-2/neu using the fluorescence in situ hybridization (FISH) technique in routinely paraffin-embedded formalin-fixed tissue has become commonplace over the past decade and mandatory among invasive breast cancer expressing a score 2+ by immunohistochemical analysis of c-erbB2 protein. The patient's eligibility for treatment with the biological drug trastuzumab/herceptin is based on the...

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Identifiers

PMID: 22417857
DOI: 10.1097/PAI.0b013e31823fb322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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