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Article

No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease.

Clinical endocrinology - 1 Mar 2005

Jennings Claire E, Owen Catherine J, Wilson Valerie, Pearce Simon H S

Abstract excerpt

OBJECTIVE: A functional polymorphism at codon 55 of the small ubiquitin-like modifier-4 (SUMO4) gene (methionine to valine; M55V) has recently been associated with type 1 diabetes mellitus (T1D). We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and autoimmune Addison's disease. DESIGN: A case-control analysis was performed using genomic DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15730420
DOI: 10.1111/j.1365-2265.2005.02224.x

Genes

SUMO4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease.PMID 15730420Read ↗

Association of SUMO4 M55V polymorphism with type 1 diabetes in Chinese children.Semantic proximity Read ↗

Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients.Semantic proximity Read ↗

Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease.Semantic proximity Read ↗

SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients.Semantic proximity Read ↗

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.Semantic proximity Read ↗

Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population.Semantic proximity Read ↗

Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.Semantic proximity Read ↗

The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis.Semantic proximity Read ↗

Association between the SUMO4 M55V Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Meta-analysis.Semantic proximity Read ↗

A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes.Semantic proximity Read ↗

No association of the SUMO4 polymorphism M55V variant in type 2 diabetes in Iranian subjects.Semantic proximity Read ↗

SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes.Semantic proximity Read ↗

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