Analysis of HIV- type 1 protease and reverse transcriptase in Brazilian children failing highly active antiretroviral therapy (HAART).

doi:10.1590/s0036-46652005000100001

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Article

Analysis of HIV- type 1 protease and reverse transcriptase in Brazilian children failing highly active antiretroviral therapy (HAART).

Revista do Instituto de Medicina Tropical de Sao Paulo - 1 Jan 2000

Machado Daisy Maria, Fernandes Silvana Cláudia, Succi Regina Célia de Menezes, Freire Wilton Santos, Pannuti Cláudio Sérgio, Gouveia Aída Barbosa, Levi José Eduardo, Diaz Ricardo Sobie

Abstract excerpt

The aim of this study was to evaluate the genotypic resistance profiles of HIV-1 in children failing highly active antiretroviral therapy (HAART). Forty-one children (median age = 67 months) receiving HAART were submitted to genotypic testing when virological failure was detected. cDNA was extracted from PBMCs and amplified by nested PCR for the reverse transcriptase and protease regions of the pol gene. Drug...

Topics

Adolescent
Adult
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Brazil
Child
Child, Preschool
Drug Resistance, Viral
Genotype
HIV Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV Protease

HIV Reverse Transcriptase

HIV-1

Humans

Infant

Mutation

Polymerase Chain Reaction

RNA, Viral

Source

Open in PubMed

Identifiers

PMID: 15729467
DOI: 10.1590/s0036-46652005000100001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15729467-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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