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Article

Rifalazil retains activity against rifampin-resistant mutants of Chlamydia pneumoniae.

The Journal of antibiotics - 1 Aug 2008

Rothstein David M, Suchland Robert J, Xia Minsheng, Murphy Christopher K, Stamm Walter E

Abstract excerpt

Rifampin-resistant mutants of the obligate intracellular pathogen Chlamydia pneumoniae were isolated and characterized, including strains that contained multiple mutations in the rpoB gene encoding the rifampin binding site. The highest MIC of rifampin against a mutant strain exceeded 100 microg/ml, whereas the highest MIC of rifalazil was 0.125 microg/ml. Derivatives of rifalazil (new chemical entities; NCEs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18997387
DOI: 10.1038/ja.2008.65

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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