Forcing reversibility in the no-strand-bias substitution model allows for the theoretical and practical identifiability of its 5 parameters from pairwise DNA sequence comparisons.

doi:10.1016/j.gene.2004.12.019

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Article

Forcing reversibility in the no-strand-bias substitution model allows for the theoretical and practical identifiability of its 5 parameters from pairwise DNA sequence comparisons.

Gene - 14 Mar 2005

Zagordi Osvaldo, Lobry Jean R

Abstract excerpt

Because of the base pairing rules in DNA, some mutations experienced by a portion of DNA during its evolution result in the same substitution, as we can only observe differences in coupled nucleotides. Then, in the absence of a bias between the two DNA strands, a model with at most 6 different parameters instead of 12 is sufficient to study the evolutionary relationship between homologous sequences derived from a...

Topics

Amino Acid Substitution
Animals
DNA
DNA Mutational Analysis
Evolution, Molecular
Humans
Models, Genetic
Mutation
Sequence Alignment
Sequence Homology, Nucleic Acid
Xenopus

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Open in PubMed

Identifiers

PMID: 15725378
DOI: 10.1016/j.gene.2004.12.019

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