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Article

Estimating changes in mutational mechanisms of evolution.

Journal of molecular evolution - 1 Jan 2003

Ota Rissa, Penny David

Abstract excerpt

By considering three DNA sequences simultaneously there is sufficient information to recover a full Markov model with three transition matrices from the root to each of the sequences. It is necessary to have relatively long sequences because, for nucleotides, the full model requires 39 parameters that are estimated from 63 observable values. This triplet Markov method is evaluated for the protein coding genes of...

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PMID: 15008420
DOI: 10.1007/s00239-003-0032-1

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