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Article

Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 2005

Rupp Jan, Hellwig-Burgel Thomas, Wobbe Viola, Seitzer Ulrike, Brandt Ernst, Maass Matthias

Abstract excerpt

Atherosclerosis is characterized by inflammation and proliferation of vascular cells. The intracellular bacterium Chlamydia (Chlamydophila) pneumoniae uses blood monocytes [peripheral blood mononuclear cells (PBMCs)] for dissemination, has been found to persist in atherosclerotic lesions, and has been implicated in atherogenesis by small GTPase activation and T lymphocyte recruitment. Infection of human coronary...

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Identifiers

PMID: 15722416
DOI: 10.1073/pnas.0407759102
PMCID: PMC552898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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