Article
Influence of the Glu298Asp polymorphism of NOS3 on age at onset and homocysteine levels in AD patients.
Neurobiology of aging - 1 Jun 2005
Guidi Ilaria, Galimberti Daniela, Venturelli Eliana, Lovati Carlo, Del Bo Roberto, Fenoglio Chiara, Gatti Alberto, Dominici Roberto, Galbiati Sara, Virgilio Roberta, Pomati Simone, Comi Giacomo P, Mariani Claudio, Forloni Gianluigi, Bresolin Nereo, Scarpini Elio
Abstract excerpt
The distribution of the Glu298Asp polymorphism in NOS3 gene was determined in 405 Italian patients with "probable" Alzheimer's disease (AD) compared with 253 age-matched controls. Total plasma homocysteine (tHcy) levels were evaluated in 97 patients and 23 controls, and were correlated with the Glu298Asp genotype. A significantly increased frequency of the Glu/Glu genotype in late onset AD (LOAD) patients was...
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