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Article

No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2000

Kunugi H, Akahane A, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S

Abstract excerpt

Recently a significant association of a missense mutation (Glu298Asp) of the endothelial nitric oxide synthase (NOS3) gene with late-onset Alzheimer's disease (LOAD) was reported. We tried to replicate this finding in a Japanese sample of 121 patients with LOAD, 51 with early-onset AD (EOAD), and 165 medical controls. However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for...

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Identifiers

PMID: 11041283
DOI: 10.1007/s007020070053

Genes

NOS3

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Related research

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No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease.PMID 11041283Read ↗

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