Article
Communication of stabilizing energy between substructures of a protein.
Biochemistry - 22 Feb 2005
Kristinsson Richard, Bowler Bruce E
Abstract excerpt
Thermodynamic communication between protein substructures has been investigated by determining the stabilizing effect of mutations at position 52 in the least stable, N-yellow, substructure of cytochrome c on the second least stable, Red, and most stable, Blue, substructures of the protein. A Lys 73 --> His (H73) variant of iso-1-cytochrome c, containing these mutations was used to measure the stability of the...
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