Article
Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression.
Molecular medicine (Cambridge, Mass.) - 1 Jan 2000
Yu Ying, Wylie-Sears Jill, Boscolo Elisa, Mulliken John B, Bischoff Joyce
Abstract excerpt
Hemangioma, the most common tumor of infancy, is characterized by rapid growth and slow regression. Increased mRNA expression of insulin-like growth factor 2 (IGF2) has been detected in the proliferating phase by cDNA microarray analysis, but the underlying mechanism causing the increase remains unknown. Here, using quantitative real-time polymerase chain reaction (PCR) and immunohistochemistry, we show that IGF2...
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