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Article

Telithromycin activity is reduced by efflux in Streptococcus pyogenes.

The Journal of antimicrobial chemotherapy - 1 Apr 2005

Cantón Rafael, Mazzariol Annarita, Morosini María-Isabel, Baquero Fernando, Cornaglia Giuseppe

Abstract excerpt

OBJECTIVES: To investigate whether telithromycin is a substrate for efflux pumps in Streptococcus pyogenes. METHODS: The distribution of telithromycin MICs was analysed for two distinct collections of Italian (n=486) and Spanish (n=210) S. pyogenes strains. The effect of an efflux mechanism was investigated using [(3)H]telithromycin. RESULTS: Telithromycin MIC ranges were < or = 0.004-0.06 mg/L (MIC(50) and...

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Identifiers

PMID: 15705635
DOI: 10.1093/jac/dki033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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