Article
High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Mar 2007
Wolter Nicole, Smith Anthony M, Low Donald E, Klugman Keith P
Abstract excerpt
A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a (69)GTG(71)-to-TPS mutation in ribosomal protein L4.
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