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Article

Mutational analysis of reduced telithromycin susceptibility of Streptococcus pneumoniae isolated clinically in Japan.

FEMS microbiology letters - 1 Jun 2010

Takaya Akiko, Kitagawa Naomi, Kuroe Yukano, Endo Kikutarou, Okazaki Mitsuhiro, Yokoyama Eiji, Wada Akihito, Yamamoto Tomoko

Abstract excerpt

A total of 132 Streptococcus pneumoniae isolates collected between 2005 and 2006 in Japan were examined for susceptibility to telithromycin (TEL) and macrolide. The overall resistance to macrolide was 80%. Among the isolates, 128 strains had low-level TEL susceptibility (minimal inhibitory concentrations [MICs] 0.03-1 microg mL(-1)), suggesting that pneumococci with reduced susceptibility to TEL have appeared...

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PMID: 20402783
DOI: 10.1111/j.1574-6968.2010.01962.x

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