Article
Mutations and deletions of the CBP gene in human lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2005
Kishimoto Masahiro, Kohno Takashi, Okudela Koji, Otsuka Ayaka, Sasaki Hiroki, Tanabe Chikako, Sakiyama Tokuki, Hirama Chie, Kitabayashi Issay, Minna John D, Takenoshita Seiichi, Yokota Jun
Abstract excerpt
PURPOSE: Microarray-based comparative genomic hybridization analysis led us to detect a homozygous deletion at the cyclic AMP response element binding protein-binding protein (CBP) locus in a lung cancer cell line. Oncogenic roles of CBP had been suggested by functional and genetic studies; thus, involvement of CBP gene alterations in lung carcinogenesis was investigated by undertaking comprehensive analysis of...
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