Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma.

doi:10.1158/1078-0432.ccr-03-0160

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Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2004

So Chi-Kwong, Nie Yan, Song Yunlong, Yang Guang-Yu, Chen Suzie, Wei Caroline, Wang Li-Dong, Doggett Norman A, Yang Chung S

Abstract excerpt

PURPOSE: Cyclic AMP response element binding protein binding protein (CBP), a nuclear transcriptional coactivator protein, is an important component of the cAMP signal transduction pathway. In this study, we systematically analyzed the pattern and frequency of CBP gene alterations in esophageal squamous cell carcinoma (ESCC) samples from Linzhou (Linxian), China. EXPERIMENTAL DESIGN: Using microsatellite markers...

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Loss of heterozygosity and internal tandem duplication mutations of the CBP gene are frequent events in human esophageal squamous cell carcinoma.

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