Are the metabolic effects of GH and IGF-I separable?

doi:10.1016/j.ghir.2004.12.003

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Article

Are the metabolic effects of GH and IGF-I separable?

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Feb 2005

Mauras Nelly, Haymond Morey W

Abstract excerpt

IGF-I mediates some, but not all of the metabolic actions of GH and it has both GH-like and insulin-like actions in vivo. GH and IGF-I both have a net anabolic effect in man enhancing whole body protein synthesis over a period of weeks and perhaps months. Both hormones favorably improve body composition in GH deficient subjects with an increase in lean body mass and decreased adiposity. This is also observed when...

Topics

Adipocytes
Adipose Tissue
Body Composition
Body Weight
Carbohydrate Metabolism
Energy Metabolism
Glucocorticoids
Growth Hormone
Humans
Insulin
Insulin-Like Growth Factor I
Lipid Metabolism
Mutation
Oxygen

Source

Open in PubMed

Identifiers

PMID: 15701568
DOI: 10.1016/j.ghir.2004.12.003

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