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Article

Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26).

The Journal of biological chemistry - 15 Apr 2005

Weihofen Wilhelm Andreas, Liu Jianguo, Reutter Werner, Saenger Wolfram, Fan Hua

Abstract excerpt

CD26 or dipeptidyl-peptidase IV (DPPIV) is engaged in immune functions by co-stimulatory effects on activation and proliferation of T lymphocytes, binding to adenosine deaminase, and regulation of various chemokines and cytokines. DPPIV peptidase activity is inhibited by both Tat protein from human immunodeficiency virus (HIV)-1 and its N-terminal nonapeptide Tat-(1-9) with amino acid sequence MDPVDPNIE,...

Read the complete abstract on PubMed

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Share to Adenosine Deaminase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to tat Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 15695814
DOI: 10.1074/jbc.M413400200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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