Article

Lymphocyte Disturbance in The [Asp521Asn] ZAP70 Mutation and An Overview of All Phenotype/Genotype

2021-05-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>. Activated Zeta (ζ)-chain-associated protein kinase 70 (ZAP70) phosphorylates the TCRαβ:CD3:ζ-complex to diversify the initial TCR signal. Patients with the ZAP70 mutations could present with the phenotype of immune dysregulation. <bold>Methods.</bold> We identified the first Taiwanese boy with the ZAP70 mutation, assessed downstream signaling, investigated lymph...

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Literature Corpus work: a6be0b59-cf03-5b9e-894b-5187e60553c4
DOI: 10.21203/rs.3.rs-494192/v1

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