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Article

Targeting Histone Deacetylases in Neuroblastoma

30 Jan 2009

Abstract excerpt

Histone deacetylases (HDACs) are an emerging class of novel anti-cancer drug targets. Recently, studies in adult cancers and in neuroblastoma have shown that individual HDAC family members are aberrantly expressed in tumors and correlate with disease stage and prognosis. In neuroblastoma, knockdown of individual HDAC family members causes distinct phenotypes ranging from differentiation to apoptosis. HDACs are...

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PMID: 19199971
DOI: 10.2174/138161209787315774

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