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Article

The search for the retinoblastoma cell of origin.

Nature reviews. Cancer - 1 Feb 2005

Dyer Michael A, Bremner Rod

Abstract excerpt

The cellular effects of the genetic defects associated with tumorigenesis are context dependent. To better understand the reasons that different cell types require distinct combinations of mutations to form tumours, it is essential to identify and characterize a tumour's 'cell of origin'. Retinoblastoma, a rare childhood cancer of the retina that is caused by RB inactivation, is a good model in which to search...

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Identifiers

PMID: 15685194
DOI: 10.1038/nrc1545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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