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Article

Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice.

Nature medicine - 1 Feb 2005

Tong Ming Han, Jiang Hong, Liu Ping, Lawson John A, Brass Lawrence F, Song Wen-Chao

Abstract excerpt

Estrogen sulfotransferase (EST, encoded by SULT1E1) catalyzes the sulfoconjugation and inactivation of estrogens. Despite decades of biochemical study and the recognition that high levels of estrogen sulfates circulate in the blood of pregnant and nonpregnant women, the physiological role of estrogen sulfation remains poorly understood. Here we show that ablation of the mouse Sult1e1 gene caused placental...

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Identifiers

PMID: 15685171
DOI: 10.1038/nm1184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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