Article
Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes.
Cellular microbiology - 1 Mar 2005
Sun Hong, Shen Yang, Dokainish Hatem, Holgado-Madruga Marina, Wong Albert, Ireton Keith
Abstract excerpt
The bacterial surface protein InlB mediates internalization of Listeria monocytogenes into mammalian cells through interaction with the host receptor tyrosine kinase, Met. InlB/Met interaction results in activation of the host phosphoinositide (PI) 3-kinase p85-p110, an event required for bacterial entry. p85-p110 activation coincides with tyrosine phosphorylation of the host adaptor Gab1, and formation of...
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