Article
GW domains of the Listeria monocytogenes invasion protein InlB are required for potentiation of Met activation.
Molecular microbiology - 1 Apr 2004
Banerjee Manidipa, Copp Jeremy, Vuga Danka, Marino Michael, Chapman Tara, van der Geer Peter, Ghosh Partho
Abstract excerpt
The Listeria monocytogenes protein InlB promotes intracellular invasion by activating the receptor tyrosine kinase Met. Earlier studies have indicated that the LRR fragment of InlB is sufficient for Met activation, but we show that this is not the case unless the LRR fragment is artificially dimerized through a disulphide bond. In contrast, activation of Met proceeds through monomers of intact InlB and, at...
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