Article
Myocardial tissue damage in rabbits injected with group A streptococci, types M1 and M22. Role of bacterial immunoglobulin G-binding surface proteins.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jan 2005
Burova L A, Nagornev V A, Pigarevsky P V, Gladilina M M, Gavrilova E A, Seliverstova V G, Totolian A A, Thern A, Schalén C
Abstract excerpt
Acute rheumatic fever (ARF) and acute poststreptococcal glomerulonephritis (APSGN), two important sequelae of streptococcal throat or skin infections, according to current concepts may be elicited by autoimmune mechanisms due to molecular mimicry between group A streptococci (GAS) and human tissue. In the case of APSGN, however, our experimental data have indicated that GAS immunoglobulin-binding surface proteins...
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