Article
Glucosyltransferases of viridans streptococci are modulins of interleukin-6 induction in infective endocarditis.
Infection and immunity - 1 Jun 2005
Shun Chia-Tung, Lu Shih-Yu, Yeh Chiou-Yueh, Chiang Chung-Pin, Chia Jean-San, Chen Jen-Yang
Abstract excerpt
The glucosyltransferases (GTFs) of viridans streptococci, common pathogens of infective endocarditis, are extracellular proteins that convert sucrose into exopolysaccharides and glucans. GTFs B, C, and D of Streptococcus mutans are modulins that induce, in vitro and in vivo, the production of cytokines, in particular interleukin-6 (IL-6), from monocytes. The roles of S. mutans GTFs in infectivity and inflammation...
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