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Article

Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis.

Journal of medical microbiology - 1 Sept 2013

Burova Larissa, Pigarevsky Peter, Duplik Nadezhda, Snegova Vlada, Suvorov Alexander, Schalen Claes, Totolian Artem

Abstract excerpt

In a rabbit model, we have previously reported evidence for a pathogenic role of streptococcal IgG Fc-binding proteins (IgGFcBP) in poststreptococcal glomerulonephritis (PSGN). These proteins, of the M protein family, were shown to trigger anti-IgG production and enhance renal deposition of IgG and/or immune complexes (ICs), with resulting activation of complement and cytokine cascades. In the present study, type...

Topics

Animals
Antigen-Antibody Complex
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins
Basement Membrane
Carrier Proteins
Carrier State
Cell Proliferation
Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genotype

Glomerulonephritis

Humans

Immunoglobulin G

Kidney Cortex

Protein Binding

Rabbits

Source

Identifiers

PMID: 23788594
DOI: 10.1099/jmm.0.059196-0

Genes

TAT
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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