Genes in familial parkinsonism and their role in sporadic Parkinson's disease.

Abstract excerpt

For several decades there has been a controversy on the contribution of genetic factors to the pathogenesis of sporadic idiopathic Parkinson's disease (PD). The identification of families in which typical parkinsonism is inherited as an autosomal dominant or recessive trait sheds light on genes that cause phenotypes resembling sporadic PD. These genes are involved in molecular pathways leading to...

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