Article
Decreased permeability and enhanced proton-dependent active efflux in the development of resistance to quinolones in Morganella morganii.
International journal of antimicrobial agents - 1 Mar 2000
Tavío M M, Vila J, Ruiz J, Martín Sánchez A M, Jiménez de Anta M T
Abstract excerpt
Five quinolone-resistant strains were developed from a clinical Morganella morganii isolate (M1 strain) which was susceptible to nalidixic acid and fluoroquinolones. All five in vitro selected mutants showed diminished norfloxacin accumulation and two of them also decreased the expression of the AgO in the outer membrane lipopolysaccharide with respect to their parent strain and to the M. morganii NCTC-235 type...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.